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Precision deuteration at metabolically vulnerable sites of pharmaceuticals can enhance drug stability and therapeutic efficacy, yet existing methods often suffer from poor selectivity and inefficiency. Here, we report an electricity-driven bromine-mediated deuteration strategy that enables late-stage site-selective deuteration of pharmaceuticals using D2O as the deuterium source. This approach involves a two-step process: (i) bromination of labile C–H bonds using Br2, followed by (ii) electricity-driven deuterodebromination using a palladium membrane reactor. This design leverages in situ Br2 generation at the anode and selective deuterium permeation through the palladium membrane cathode, thereby significantly improving atom economy and energy efficiency. Our method achieves nearly complete conversion and >90% deuterium incorporation for a range of aryl, heteroaryl, benzylic, and unactivated alkyl bromides, including ten marketed drug molecules. Furthermore, gram-scale synthesis of D-clonidine demonstrates the scalability of this approach. By integrating high selectivity, broad substrate scope, and operational efficiency, this method offers a practical solution for deuterated drug synthesis, with potential applications in pharmaceutical development and metabolic stabilization. 

Abstract Functional unit and organization (FUO) paradigm starts with functional units and assembles these functional units into specific organizations to optimize material performance. An advantage of FUO paradigm is interpretation of physical essence of traditional structure–performance relationships. Experimental achievements based on FUO paradigm abound in recent years, demanding theoretical explanations for further quantitative material design. Following FUO paradigm, here a three‐step model (bond‐region‐structure) of nanotwin (NT) unit and orientation organization to optimize mechanical performance is established. First, anisotropic elasticities of representative bonds and assembled regional elastic constants are evaluated. Second, yield conditions of different regions, which are summarized as critical resolved shear stress (CRSS) criteria of NT structure, are quantified. Third, anisotropic yield strengths of NT structure from the regional elastic constants and CRSS criteria are derived. This FUO‐based model is implemented into InSb, GaAs, and ZnS, predicted elastic constants and yield strengths are validated with molecular dynamics (MD) simulations. The method is more efficient than MD with comparable accuracy, and is also flexible to combine with density function theory and experiment. This demonstration sets foundation of NT unit and orientation organization design for achieving optimum mechanical performance. 

Abstract The broad employment of water electrolysis for hydrogen (H 2 ) production is restricted by its large voltage requirement and low energy conversion efficiency because of the sluggish oxygen evolution reaction (OER). Herein, we report a strategy to replace OER with a thermodynamically more favorable reaction, the partial oxidation of formaldehyde to formate under alkaline conditions, using a Cu 3 Ag 7 electrocatalyst. Such a strategy not only produces more valuable anodic product than O 2 but also releases H 2 at the anode with a small voltage input. Density functional theory studies indicate the H 2 C(OH)O intermediate from formaldehyde hydration can be better stabilized on Cu 3 Ag 7 than on Cu or Ag, leading to a lower C-H cleavage barrier. A two-electrode electrolyzer employing an electrocatalyst of Cu 3 Ag 7 (+)||Ni 3 N/Ni(–) can produce H 2 at both anode and cathode simultaneously with an apparent 200% Faradaic efficiency, reaching a current density of 500 mA/cm 2 with a cell voltage of only 0.60 V. 

Abstract One-photon-absorbing photosensitizers are commonly used in homogeneous photocatalysis which require the absorption of ultraviolet (UV) /visible light to populate the desired excited states with adequate energy and lifetime. Nevertheless, the limited penetration depth and competing absorption by organic substrates of UV/visible light calls upon exploring the utilization of longer-wavelength irradiation, such as near-infrared light (λ irr  > 700 nm). Despite being found applications in photodynamic therapy and bioimaging, two-photon absorption (TPA), the simultaneous absorption of two photons by one molecule, has been rarely explored in homogeneous photocatalysis. Herein, we report a group of ruthenium polypyridyl complexes possessing TPA capability that can drive a variety of organic transformations upon irradiation with 740 nm light. We demonstrate that these TPA ruthenium complexes can operate in an analogous manner as one-photon-absorbing photosensitizers for both energy-transfer and photoredox reactions, as well as function in concert with a transition metal co-catalyst for metallaphotoredox C–C coupling reactions. 

WISE J224607.6–052634.9 (W2246–0526) is a hot dust-obscured galaxy atz = 4.601, and the most luminous obscured quasar known to date. W2246–0526 harbors a heavily obscured supermassive black hole that is most likely accreting above the Eddington limit. We present observations with the Atacama Large Millimeter/submillimeter Array (ALMA) in seven bands, including band 10, of the brightest far-infrared (FIR) fine-structure emission lines of this galaxy: [OI]_63 μm, [OIII]_88 μm, [NII]_122 μm, [OI]_145 μm, [CII]_158 μm, [NII]_205 μm, [CI]_370 μm, and [CI]_609 μm. A comparison of the data to a large grid of CLOUDYradiative transfer models reveals that a high hydrogen density (n_H ∼ 3 × 10³cm⁻³) and extinction (A_V ∼ 300 mag), together with extreme ionization (log(U) = − 0.5) and a high X-ray to UV ratio (α_ox ≥ −0.8) are required to reproduce the observed nuclear line ratios. The values ofα_oxandUare among the largest found in the literature and imply the existence of an X-ray-dominated region (XDR). In fact, this component explains the a priori very surprising non-detection of the [OIII]_88 μmemission line, which is actually suppressed, instead of boosted, in XDR environments. Interestingly, the best-fitted model implies higher X-ray emission and lower CO content than what is detected observationally, suggesting the presence of a molecular gas component that should be further obscuring the X-ray emission over larger spatial scales than the central region that is being modeled. These results highlight the need for multiline infrared observations to characterize the multiphase gas in high redshift quasars and, in particular, W2246–0526 serves as an extreme benchmark for comparisons of interstellar medium conditions with other quasar populations at cosmic noon and beyond.